Was out delivering yesterday… three totally different conditions. ..adhd in a little boy…arthritis in a dog and leukaemia in an elderly lady…. all will benefit… I find animals it works so quick with and not much is needed… I’m always amazed by this #cbd #cannabis #hemp #energy #reiki #marijuana #spiritualgoal https://www.instagram.com/p/CNUGRc1MzZZ/?igshid=1fr5krpl2fhok
So, where does the connection between CBD and skin cancer begin? A number of studies have found a link between CBD, the body’s endocannabinoid system, and gene regulation that prevents cancer growth. Here’s an overview of the pertinent research.
CBD contains substances known as cannabinoids, natural compounds that interact with the receptors of the endocannabinoid system. This network of receptors is scattered across the body, where it regulates a wide array of functions that include mood, pain and inflammation, and cell growth. When the abnormal cells that cause skin cancer grow, the endocannabinoid system isn’t functioning properly.
Studies have shown that CBD can help endocannabinoid receptors return to normal function and halt the progress of skin cells that are turning cancerous. Early evidence indicates that cannabinoids work to “regulate cell-survival and cell-death pathways differently in tumor and non-tumor cells,” suggesting that compounds like CBD can possibly be used to target cancerous growths without damaging healthy cells. A 2013 study reported that 90% of skin cancers could be mitigated using synthetic cannabinoids. In this preliminary research, CBD has shown promising results in preventing the growth and metastasization of cancer cells, providing a potential alternative to traditional treatments like chemotherapy without harmful side effects.
It’s important to note that many of these studies have been conducted on animals, and research on the link between CBD and skin cancer remains in the very early stages of development. One 2017 report noted that “preliminary studies have suggested cannabis and its derivatives might have use in acne, dermatitis, pruritus, wound healing, and skin cancer. Further well-controlled studies are required to explore these potential uses.”
How To Use CBD Oil For Skin Cancer
CBD oil can be administered to a patient in a variety of ways. There are tinctures, which can be squirted under the tongue for quick absorption via the mucous membranes. Tincture oil can also be applied directly to the skin for absorbtion.
CBD capsules and candy edibles are also available that work from the inside out.
Topical application means that the CBD oil would mainly interact with the upper levels of the epidermis. On the other hand, taking CBD orally will allow the compound to reach more throughout the body.
It is important to note that an oral route of administration would result in higher overall levels of CBD in the patient’s bloodstream.
These statements have not been evaluated by the Food and Drug Administration. Products discussed are not intended to diagnose, treat, cure, or prevent any disease.
Due to FDA Regulations, we recommend that you do your own research on CBD products. We also suggest that you read the reviews on our website, where our customers record their real-world results of using our products.
Is CBD safe for kids?? This is a huge topic especially for those parents with sick children and are at their wits end on what to try. Have a little read from the article I found on puregreen living and decide for yourself
Is It Safe?
CBD oil has been gaining lots of attention when it comes to helping children with autism, sensory processing disorders, anxiety disorders, insomnia, epilepsy and more, and there are many studies, as well as scientific evidence showing that CBD oil can be of benefit for various kinds of health issues affecting children.
Many sites document successful experiments in treating children using CBD Oil. Although more research still needs to be done, findings so far indicate that CBD is safe for children.
Children are actually exposed to external sources of cannabinoids quite frequently, even as early as birth through their mother’s breast milk which is an abundant source of endocannabinoids, and which assists with infant development. So cannabinoids are not new to the body system of a child, and it has had a huge role to play in child development.
CBD oil is known to assist the body in creating more of its own cannabinoids which in turn aid the body in operating properly. We should note that CBD is a form of Cannabinoid found in cannabis plants. It’s different from another Cannabinoid known as tetrahydrocannabinol (THC), which is the ingredient that gives that high or stoned feeling when ingested.
Since there are no psychoactive properties in a true CBD hemp oil, children are not at risk of getting that “high” feeling associated with cannabis products heavy in the cannabinoid cousin THC. So you don’t have to worry about your children experiencing that high feeling, should you use CBD oil on them.
Existing CBD Use On Children
CBD oil has been used for children with health issues. In countries like the United States, Australia, Brazil, Israel, the United Kingdom and Ireland, success stories involving administering CBD oil for kids abound.
One of them is the famous story of Charlotte Figi who was given CBD oil to help calm her seizures. Charlotte was diagnosed with Dravet syndrome, a condition which causes seizures and paralysis in the body. She was experiencing more than 300 epileptic seizures every week and she could neither move, talk nor eat on her own. When doctors ran out of solutions, her mother purchased CBD Oil at a local marijuana dispensary, and this totally changed their lives.
Charlotte’s seizures fell to fewer than one episode per week, and she stayed virtually seizure free throughout the entire first week of treatment. Due to the success in calming her seizures, the cannabis strain was named in her honor and it’s often used to treat chronic pain, anxieties, seizures, and stress among both children and adults.
Another is the story of Katelyn Lambert in Australia, whose grandfather was so thrilled by the effectiveness of CBD oil in lowering his granddaughter’s seizures that he donated $34 million (Aus) to medical cannabis research.
Then there’s the story of Ava Barry in Ireland, who like Charlotte was also diagnosed with Dravet syndrome. She had already been sent home by doctors, who had told her parents that there was nothing else they could do. But her parents wouldn’t give up, and after researching on the internet, they started giving Ava CBD oil, which reduced her seizures by over 80%. Apart from the notable reduction in seizures, Ava’s parents also saw a noticeable improvement in her overall well being and cognitive ability. “she was standing up straighter” her mother says. “She was making more eye contact and the next thing, in a family joke, Ava was giggling just like the other kids. She had never laughed like that before.
As of now, since research has not proven otherwise, there is absolutely no harm in administering CBD oil to children who really need it. It has been said to be completely safe as it doesn’t cause stunted growth either physically or mentally.
Studies have shown that CBD is a safe alternative for children who need medication. This was made official by the World Health Organization in December 2017 after conducting extensive research. The WHO stated that it found no adverse risks in using CBD, and proclaimed it as of “relatively low toxicity” and having “a good safety profile”.
For parents of sick children with seizures and other related disorders who seem to have run out of solutions and medications, CBD Oil drop is worth a try.
Where can I get CBD oil?
CBD is becoming readily available in health stores. Earlier this year, CBD oil launched at Holland & Barrett, starting at £19.99
However, Professor McGuire says it’s easy to get confused about what exactly it is that you’re buying. “The products sold in health stores often contain very small amounts of CBD, and may also be mixed with other compounds derived from cannabis.
“There is little evidence that these products have beneficial effects. In contrast, the CBD that has been found to be effective in clinical trials is pure CBD, and has a much higher dose.”
What percentage of CBD should I look for?
This will depend on what you’re looking to get from the oil.
The CBD oils sold in Holland & Barrett and other health stores contain up to 5% CBD. This can be beneficial when used as a health supplement.
Other oils available online contain up to 20% CBD – the most famous being ‘Charlotte’s Web’. Many claims have been made that products like these can alleviate mild to moderate mental health problems, such as anxiety and depression.
Here are 4 standards to look for when purchasing CBD medical hemp oil.
1. Extraction Methods
To obtain CBD-rich oil, you need to extract it from the cannabis plant. There are a handful of methods used, but typically this isn’t something customers know to ask about.
Not surprisingly, many companies use cheap methods that involve nasty toxic solvents such as propane, hexane, pentane, and butane, which are flammable hydrocarbon gases found in petroleum. Do you really want to consume this, especially if you are ill?
“Cannabis oil made with neurotoxic solvents like butane and hexane may leave unsafe residues that compromise immune function and impede healing,” explainsConstance Finley, founder and CEO of Constance Therapeutics.
Beware of companies who try to convince you that using a hydrocarbon method stays the most true to the plant. Butane is illegal for a reason.
“Butane extraction is cheap and efficient but is toxic to make and use,” adds cannabis and medicinal plant expert Medicine Hunter Chris Kilham. “Inhalation of butane residue can cause cardiac and respiratory problems.”
Some industry insiders argue that organic, pharmaceutical-grade ethanol, which is a grain alcohol, is optimal and eliminates certain toxins and residues in the raw plant material itself. But others say that while this extraction method yields a high amount of cannabinoids and is GRAS (Generally Recognized as Safe) for human consumption, it destroys the plant’s waxes, leading to a less potent oil.
Conversely, to preserve most of the plant’s trichromes – these are the cannabinoids, terpenes, and flavonoids – look for Supercritical (or subcritical) CO2 extraction. This method uses carbon dioxide under high pressure and extremely low temperatures to isolate, preserve, and maintain the purity of the medicinal oil. While this method is more expensive and involves complex equipment and expertise, it ensures quality.
“The CBD oil obtained through supercritical extraction is a full-spectrum cannabinoid-rich product,” says Elizabeth Moriarty, Clinical Herbalist and Formulator at Luminary Medicine Company. “This method also produces a cleaner taste, and meanwhile, mycotoxins cannot survive this process.”
It’s also eco-friendly and non-flammable, creating a safer laboratory and manufacturing environment, as well as better product control, says Gabriel Ettenson, licensed physical therapist and general manager of Elixinol, an organic Hemp CBD Oil company.
Finally, olive oil or coconut oil can also be used to extract cannabis oil. According to Dr. Arno Hazekamp, director of phytochemical research at Bedrocan BV, which supplies medical cannabis for the Dutch Health Ministry, this method is both safe and inexpensive. “You won’t blow yourself up making cannabis-infused olive oil.”
With that said, cannabis-infused olive oil — whether CBD-rich or THC-dominant — is perishable and should be stored in a cool, dark place.
The quality of CBD oil is really based on its source; where was it grown, how was it grown, and what is the species of cannabis (e.g., sativa, ruderalis, or indica).
“The soil, climate, plants growing on the farm next door, the flowers in the farmer’s garden, etc. are all reflected in the final essence of the plant,” says Finley.
The main reason why hemp’s cultivation environment is so important is because the cannabis plant is a “hyperaccumulator,” meaning it easily absorbs contaminants from the soil while it grows. In fact, it’s used in bioremediation, a cost-effective plant-based approach to clean the environment of toxic heavy metals and organic pollutants.
“This is sadly why industrial hemp grown in non-food grade conditions is falsely being sold as CBD medicine over the internet,” says Finley.
So if the soil is polluted with heavy metals, then that plant will likely contain high levels of lead or mercury. According to Frias, there have been instances where children have almost died taking hemp extracts that were high in lead.
Essentially, “those companies have given the rest of the CBD industry a black eye because they were more interested in profiting off the sick instead of creating a quality product and testing it.”
Look for brands who source their cannabinoids from organic-certified, hemp-grown farms in pristine regions of Europe. “The German regulatory system is strict and enforced, providing confidence in the superiority of their harvest, processes, and extraction quality,” adds Moriarity.
Meanwhile, independent testing by accredited laboratories with globally accepted analytical methods ensures the organic extract is intact from pesticides, heavy metals, or microbiological contaminants. And reputable CBD companies have lab results from independent labs available on their websites, this can also be used as an indicator for consumers about what companies are providing high-quality CBD.
When it comes to the “best” genotype, it really depends upon what one is hoping to treat or effect.
Unfortunately, there have been instances where products claiming to have CBD in them tested at zero percent in a lab attempting to verify the results. In fact, in 2015, the Food and Drug Administration (FDA) tested products and fined companies that did not include any CBD despite reports. This also gives the industry a proverbial black eye.
So let’s say you are dealing with a product that contains CBD, the amount that actually enters the body and central nervous system is still a gray territory. In food products, cannabinoids are subject to degradation and reduced bioavailability, depending on overall formulation/delivery.
“The industry is pushing for more research here, as these studies on cannabis are relatively very new,” explains Joe Santucci of Solstice, a commercial cannabis production company. “CBD can be an amazing, but a very expensive solution for those that need it, so maximizing bioavailability is going to be essential to lower the cost for people.
“In terms of ingestion, the general consensus is that sublingual (under the tongue) and/or rectal delivery provide the highest levels of bioavailability,” says Ettenson. Some believe that vaping also produces high bioavailability as well. “Topical and ingestion (through soft gels for example) have lower levels of absorption,” says Gabriel.
If you are vaporizing CBD-dominant strains of cannabis, bioavailability is through the alveoli, tiny sacs in the lungs, clarifies Kilham. If you are taking CBD strain capsules, he suggests eating some fat or oil, like a handful of nuts or some full-fat yogurt, to improve absorption and bioavailability. Cannabinoids are fat-loving molecules. They are taken up readily into the small intestine with a bit of dietary fat.
“The need for enhanced bioavailability of the CBD phytonutrient is paramount”, adds Moriarity, “but tricky to accomplish without synthetic chemicals.” Most CBD products do not offer any bioavailability optimization, so 90 percent of the CBD is lost to first-pass effect, a phenomenon of drug metabolism whereby the concentration of a drug is greatly reduced before it reaches systemic circulation.
Meanwhile, the products that do engage in optimization efforts “are generally using a synthetic chemical soup of solvents, surfactants, and emulsifiers — none of which must be disclosed on the label since they are characterized as ‘processing aids,’” says Moriarty, who co-formulated our Superior cannabinoid oil, the market’s leading solution.
The formulation, however, offers optimized delivery via mucosal membrane permeability in tandem with precision production/formulation methods. Her company, HERBOLOGIE, reduces the particle size of the cannabinoids and immerses them in a matrix of exclusively natural ingredients that work synergistically to enhance absorption through oral membranes. When cannabinoids are transported through membranes and directly into the bloodstream, the phytonutrients are delivered more quickly, and crucially, avoiding first-pass degradation in the liver.
“We know the manufacturing process can also influence bioavailability,” says Ettison. “For example, reducing the size of the CBD compound through the use of liposomes improves absorption and bioavailability.”
“When purchasing a CBD product, keep in mind that a transparent company’s CBD milligram (mg) strength is reflective of the actual active CBD in that particular product,” states Farias. “If a bottle says 250 mg of CBD, then that product should contain 250 mg of actual active CBD. However, a lot of companies currently in the market will list the mg dosage of their CBD hemp oil without publishing the strength of their actual active CBD.”
Ideally, look for CBD products that proportionately offer 4 or more parts CBD to 1 part THC, for maximum relief and minimal or no storage issues.
4. Greenwashing Tactics
Upon investigation there are companies that engage in the use of “window dressing.” For example, one popular brand brags that they use the superfood moringa. This of course lures people in. But keep in mind that for added antioxidant benefit, you would need to ingest 7.5 g (7,500 mg) within the context of a meal or beverage. The entire 30 ml bottle of said brand contains 33.3 mg; so at the recommended dose of 1 ml daily, the daily dose of moringa would only be 1.11 mg.
“The truth is that the gray zone of medicinal cannabis invites lots of shady characters into the burgeoning industry,” says Finley. “A lack of critical thinking, quality business practices, transparency about products and plants, all have been part of the black market.”
“When the conditions are “primed” in these four areas, you set a high standard of quality for the whole plant efficacy, and CBD can provide outstanding health benefits for longevity and wellness in high grade medicinals used for health repair,” says Cherie Arnold, Founder and CEO of MediQI Energetics.
Look for products that are sold legally, with full transparency.
A groundbreaking new medical study may have determined that cannabis treats ADHD symptoms better than conventional medicines, like Ritalin and Adderall.
A small sample of 30 patients with ADHD took part in a study to demonstrate the ways in which cannabis treatments can affect their symptoms. These patients said they were having limited success with Ritalin and Adderall. After their cannabis treatment, all 30 patients reported a significant improvement in their concentration levels and their quality of sleep, and 22 of the 30 patients have stopped using ritalin/adderall since
ADHD cannot be prevented or cured but spotting it early and having a good treatment can significantly diminish the symptoms.
“Cannabis appears to treat ADD and ADHD by increasing the availability of dopamine,” said cannabinoidologist, Dr. David Bearman. “This then has the same effect but is a different mechanism of action than stimulants like Ritalin and dexedrine amphetamine, which act by binding to the dopamine and interfering with the metabolic breakdown of dopamine.”
If the key to higher concentration levels and better sleep is more dopamine then cannabis use can be combined with many other natural dopamine heightening activities to further decrease ADHD symptoms.
Due to the fact that CBD produced promising results in a variety of mental disorders, specialists wonder if it could help ADHD patients as well. Considering that when ADHD is present in the brain of a person, the signs are elevated cortisol levels and low dopamine levels.
Which explains the constant state of irritation and the inability to calm down and relax, CBD could help by lowering cortisol and inducing a state of calmness.
While it is true that there is a specific medication that is prescribed in the case of ADHD patients, many complain about the unpleasant side-effects they produce, like constant headaches which often lead to a decrease in the quality of sleep.
Those that gave CBD oil a chance, said that the new treatment stopped their headaches and gave them the possibility, for some the first time in their lives, to actually get a hold of their mind.
No risks of negative side-effects
CBD has nothing to do with an addictive substances and will not alter the perception ability of a person, this is why one can use CBD at any time during the day or night.
Plus, even if you decide to adopt this treatment for a long-term, you will not experience the “need” to take it, as the body will not develop any form of addiction toward it.
This is because the human body was designed to produce cannabinoids in a natural manner. Problems occur when these cannabinoids are not produced as it should.
The medication available for ADHD is meant to stimulate the production of dopamine, a chemical that is usually produced by the brain, responsible for our ability to unroll cognitive processes, like memorizing things and focusing on our activities.
Due to this fact, CBD reacts so well in our body, as the cannabinoids it contains will immediately bind with the right kind of receptors, restoring the balance in a way that no drugs can.
But, in the case of ADHD patients, there is an issue with dopamine, as the brain is not producing sufficient dopamine. According to the latest researches, CBD can do the same as specialized ADHD medication and that is to stimulate the production of dopamine and improve the brain function.
Thus, the cannabinoids, which are the active components of CBD oil, has a great potential at improving the state of mental health in people suffering from ADHD, making dopamine more available to their brains.
And the best part about this treatment is that it is safe to be used in the case of children as well, as it doesn’t trigger any addictions or unwanted psychoactive effects.
Important Facts To Know About CBD Oil For ADD And ADHD
- CBD oil not only interacts with the endocannabinoid system, but it also binds with serotonin receptors, vanilloid receptors, and adenosine receptors that have a significant impact on stress and pain management, mood management, and sleep-wake cycles.
- CBD oil was classified as a nutritional supplement, but after recognizing many health benefits, it is considered as a medicine by the British government.
- ADHD causes disturbances in the sleep cycle; however, CBD oil works as a sedative that helps in treating insomnia.
- CBD oil is non-toxic; therefore, even excessive intake of CBD oil causes no severe side effects, and it is nearly impossible to overdose.
- CBD oil consists of a very minute amount of THC; therefore, it is safe and quite effective in treating depression, anxiety, paranoia, and stress without making you high.
- A study conducted in 2013, revealed that CBD oil helps in blocking the addictive impact of painkillers like morphine. It protects the body from dealing with any severe side effects.
No reason to not give this a go, no side effect only a tonne of amazing benefits.
If you suffer from stress or related conditions such as anxiety and depression, you certainly aren’t alone.
These are two of the most common illnesses in the world, but fear not; there are many natural ways you ease your stress. Spending more time in nature, yoga and CBD products all harness the power of nature to heal and balance our bodies.
Over the past decade, numerous studies have revealed that yoga has the ability to significantly lower levels of the stress hormone, cortisol. Thus, this ancient practice is used in everything from cancer therapy, to substance abuse recovery, eating disorder recovery, Post Traumatic Stress Disorder, and even recovery from breast cancer.
Researchers believe that stress relief comes from three major sources: the yogic asanas or poses (which involve intense coordination between body and mind), controlled breathing (which lowers the heart and breathing rates) and mindfulness (yoga is often accompanied by meditation, which aims to keep us “in the present moment”).
Mindfulness is one of the most powerful ways we can stop stress in its tracks, because it allows us to escape the frequent ruminations about the past or worry about our future. When we keep the mind in the here and now, we are able to breathe better, focus more, and create a mental state that is incompatible with panic attacks and general anxiety.
YOGA AND CBD FOR STRESS
CBD is increasingly being used to battle stress, owing to its ability to react directly with cell receptors, including serotonin and dopamine receptors. It is vital not to confuse CBD with THC (the cannabinoid responsible for the ‘high effect’ of marijuana). While THC can have many benefits, CBD offers numerous positive effects for its users while leaving their mental state mostly unchanged.
CBD is often taken as an oil but also used topically to treat skin conditions and inflammation, or even consumed in sweets like gummies. It is just one of the many naturally occurring compounds found in all cannabis plants. Because of how CBD interacts with serotonin and dopamine receptors in the brain and nervous system, more of these neurotransmitters can flow through the body, resulting in a greater sense of calm and wellbeing.
A MULTI-LAYER APPROACH TO BATTLING STRESS
If you think you may have anxiety or depression, it is important to check in with a doctor. Working alongside your therapist or other health professional, you can take many approaches to battling these conditions.
It is important to tackle stress from a multi-layered perspective, too. Holistic activities , Tai Chi, mindfulness meditation, and time spent in nature have proven to be a useful complementary therapy for anxiety and other stress-related conditions. CBD, an almost miraculous supplement made from natural hemp, can be an important part of our anti-stress toolkit too.
Whatever approach you take, if you make time to care for yourself and your wellbeing then every other part of your life will seem a little bit easier.
Patent No. 6630507, held by the United States Department of Health and Human Services, covers the use of cannabinoids for treating a wide range of diseases.
Under U.S. federal law, marijuana is defined as having no medical use. So it might come as a surprise to hear that the government owns one of the only patents on marijuana as a medicine.
The patent (US6630507) is titled “Cannabinoids as antioxidants and neuroprotectants” and was awarded to the Department of Health and Human Services (HHS) in October 2003.
It was filed four years earlier, in 1999, by a group of scientists from the National Institute of Mental Health (NIMH), which is part of the National Institutes of Health (NIH).
The government’s patent does not cover THC, the main ingredient in marijuana. On the other hand, cannabidiol (CBD) is specifically mentioned as an example of a cannabinoid that is covered. The patent describes CBD and other non-psychoactive cannabinoids as superior when taken in higher doses.
“Nonpsychoactive cannabinoids, such as cannabidiol, are particularly advantageous to use because they avoid toxicity that is encountered with psychoactive cannabinoids at high doses.”
According to the description, CBD can be ingested in very large amounts without side effects.
“No signs of toxicity or serious side effects have been observed following chronic administration of cannabidiol to healthy volunteers, even in large acute doses of 700mg/day.”
The patent explains that cannabidiol previously had not been considered useful as a neuroprotectant. However, it cites various studies on cannabidiol as an antiepileptic and as a potential treatment for glaucoma.
Other great reads on the Cannabis Conspiracy
There are cannabinoid receptors in all areas of the female reproductive organs, including both the CB1 and CB2 receptors. Given what we already know about CBD’s influence over these receptors, it’s a logical assumption to believe that CBD could help reduce the signs and symptoms of menopause through interaction in the highly concentrated areas of endocannabinoid receptors.
Bone Density Loss
0By Julia Granowiz
Have you ever wondered why marijuana affects us the way it does? What is it that makes THC and CBD react with our bodies, healing and offering relief to the ill? What makes this plant such a diverse medicine, able to treat such a large number of vastly different conditions?
If you had asked this question fifty years ago, there wouldn’t have been an answer for you to find. Unfortunately, the extraction methods available in the early 1900s made it difficult to determine which one of the 80+ cannabinoids found in cannabis was the psychoactive cannabinoid responsible for the effects of marijuana.
The truth is, it’s only been in the last couple of decades that scientists have truly even begun to understand the ways cannabis works within our bodies.
Soon after this discovery researchers started using a synthetic form of THC (which is actually FDA approved these days, to treat severe nausea and wasting syndrome) to start mapping the CB receptors in the brain. Not much of a surprise, the receptors were located primarily found in the regions responsible for mental and physiological processes including memory, higher cognition, motor coordination, appetite and emotions among other places.
When THC was given to the “knockout mice” as they were called, they found that because the THC had nowhere to bind, there was no way to trigger any psychoactive activity – proving once and for all that THC works by activating specific cannabinoid receptors in the brain and central nervous system.
Soon after, in 1993, a second cannabinoid receptor was found – as a part of the immune and nervous systems. Dubbed CB2 (the CB receptors in the brain officially dubbed CB1 receptors) receptors they are found to be plentiful throughout the gut, spleen, liver, heart kidneys, bones, blood vessels, lymph cells and even the reproductive organs.
However that curious, pesky question remained unanswered – why do we have cannabinoid receptors in the first place?
The answer to that question started to unfold in 1992, when the first endocannabinoid was discovered. Anandamide was the first, naturally occurring endogenous cannabinoid, or endocannabinoid. It was found by Raphael Mechoulam as well as NIMH researchers William Devane and Dr. Lumir Hanus.
This is still only one of two known and relatively well-understood endocannabinoids. It attaches to the same CB receptors as THC and it was named after the Sanskrit word for bliss.
A second endocannabinoid was identified in 1995, discovered by none other than Mechoulam’s group yet again. This second major endocannabinoid was dubbed 2-arachidonoylglycerol or “2-AG” to keep it simple. This particular endocannabinoid attaches to both CB1 and CB2 receptors.
It was these discoveries, working backwards, tracing the metabolic pathways of THC, which allowed scientists to discover an entirely unknown molecular signaling system that resides within us – and within thousands of other biological lifeforms, basically everything on our planet with the exception of insects.
Due to the role cannabis played in discovering this system it was rightfully named the endocannabinoid system. While we knew about the plant first – this cellular process has been happening within us for millions of years. According to Dr. John McPartland, the system started evolving as long ago as 600 million years back – when complex life meant a sponge.
There is evidence that a possible third CB receptor has still gone unidentified, thirteen years after the CB2 receptor was initially discovered.
Since then, we have found out that the endocannabinoid system is responsible for maintaining many of our normal bodily functions – everything from helping to maintain healthy bone density (as found in a study with mice and the previously mentioned “knockout mice”) to naturally preventing diabetes – and that’s only the beginning.
It’s interesting to see how far we’ve come – fifty years ago THC had just been identified – now, thanks to the discovery of that one cannabinoid we’ve discovered an entire molecular system within our bodies that we never knew about.
Actually, the endocannabinoid system is possibly the single-most important system within our entire bodies – responsible for maintaining homeostasis. Basically, if our endocannabinoid system is out-of-whack, your whole body could be at risk as it is responsible for many of our normal day to day functions.
Is it so hard to think that if supplementing unbalanced naturally occurring endocannabinoids with the cannabinoids from cannabis is able to manage, relieve or control a condition (such as ALS, Parkinson’s or Alzheimer’s) and even cure cancer – that it might be possible to use the same process to prevent such conditions in the first place?
“I now believe the answer is yes. Research has shown that small doses of cannabinoids from cannabis can signal the body to make more endocannabinoids and build more cannabinoid receptors. This is why many first-time cannabis users don’t feel an effect, but by their second or third time using the herb they have built more cannabinoid receptors and are ready to respond. More receptors increase a person’s sensitivity to cannabinoids; smaller doses have larger effects, and the individual has an enhanced baseline of endocannabinoid activity. I believe that small, regular doses of cannabis might act as a tonic to our most central physiologic healing system.” – Dustin Sulak, DO (Taken from a blog post from NORML.org)